AlphaLISA
Alpha is a bead-based, no-wash luminescent technology. When Alpha Donor and Acceptor beads are brought together through binding to target, a cascade of chemical reactions is set in motion, creating an amplified signal. These versatile beads are conjugated with various biomolecules that enable detection of unique biological events, offering maximum flexibility.
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Alpha technology is compatible with a wide range of sample types ranging from simple buffers, cell supernatants, and cell lysates to complex tissue, serum, plasma, and other biological samples.
Alpha offers benefits including:
- Faster time to results
- Ability to quantitate large protein complexes, nucleosomes, and viral particles
- Option for multiplexing
Virtually any target can be quickly and easily measured using Alpha technology, an improved alternative to quantitative ELISA assays and ELISA reagents. Such targets include enzymes, receptor-ligand interactions, low-affinity interactions, second messenger levels, DNA, RNA, proteins, protein-protein interactions, peptides, sugars and small molecules.
- Ease-of-use: homogeneous assay with no wash requirement and no separation steps
- Fast: results in 3 hours for most applications
- High sensitivity: detect down to femtogram levels of target
- Large dynamic range: 4-5 logs
- Compatible with many samples types: serum, plasma, cerebrospinal fluid (CSF), tissue extracts, cell culture supernatants, cell lysates, and more
Choose the homogenous assay right for you:
- AlphaLISA® – when running large numbers of ELISA assays from the same sample or working with a difficult matrix, serum or plasma
- AlphaLISA SureFire®Ultra™ – an excellent choice for studying pathways or phosphorylated proteins in whole cells, or studying endogenous receptors
- AlphaScreen® – perfect for studying fusion-tagged proteins or protein-protein interactions, and for testing cAMP, phosphorylated peptides or samples in a simple matrix
- Alpha Toolbox – when your target doesn’t have an off-the-shelf quantitative ELISA assay, the toolbox gives you everything you need to create your own
Accelerate your cell and gene therapy development
The promise of cell and gene therapies as the next generation cure for oncological and rare inherited genetic diseases is being realized. Their potential has driven a rapid expansion in both preclinical and clinical research and development.
The increasing complexity of cell and gene therapy genomic edits required to treat multifactorial diseases, and the need for precision-targeted delivery systems, is driving continual innovation aimed at expediting the availability of these life-saving treatments to patients.
This infographic provides an overview of Revvity's comprehensive cell and gene therapy solutions, emphasizing the role of innovation and automation in streamlining the therapy development workflow.
