New Multi-Angle Light Scattering Detector for Protein and Polymer Characterization

Wyatt Technology, a leader in instrumentation for absolute macromolecular and nanoparticle characterization, announces the launch of its next generation multi-angle light scattering (MALS) detector for SEC/GPC, the miniDAWN^® TREOS^® II. The TREOS II is the only SEC-MALS detector for size exclusion or gel permeation chromatography that offers full field serviceability, extended ease-of-use, and a built-in upgrade path from HPLC to UHPLC technology.

The miniDAWN TREOS II interfaces to most HPLC-SEC systems to characterize all types of macromolecules and nanoparticles in solution with radii below 50 nm, from 200 Da to 10 MDa. This range covers most proteins, peptides and small polymers. It provides superior sensitivity for its class of compact MALS detectors, robustly measuring the molar mass and size of as little as 25 ng of 100 kDa polystyrene when using standard GPC columns. This level of performance is 4x better than competing light scattering instruments. With the addition of a WyattQELS embedded dynamic light scattering module, the TREOS II can simultaneously determine hydrodynamic radius (rh) from 0.5 to 50 nm and rms radius (rg) from 10 nm to 50 nm.

Continuing a tradition of excellence in meeting the most demanding needs of its customers, Wyatt has ensured that its next-generation MALS detector combines improved performance with higher productivity.