ResourceDrug discovery > Basic Research
Determination of the acid dissociation constant
9 Oct 2025Understanding the acid dissociation constant (pKa) is essential for drug development, regulatory compliance, and predicting molecular behaviour in biological environments. Accurate pKa determination supports formulation decisions and helps assess how drug molecules interact with target sites under varying pH conditions.
Discover how spectrophotometric techniques enable reliable pKa measurement, supporting pharmaceutical, life sciences, and agrochemical research with precision and efficiency.
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UV-Visible SpectroscopyUltraviolet-visible (UV-Vis) spectrophotometers are used to measure the interaction of UV and visible light with a sample, including transmission, reflectance & absorbance. The two major instrument classes are single-beam or double-beam spectrophotometers. More specialized equipment includes colorimeters, spectroradiometers and refractometers. Portable and microvolume spectrophotometers are also available. For the modular spectroscopy lab, explore a range of light sources for combination with a spectrograph/spectrometer and optics. Find the best UV-Vis spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.TitrationTitration is an analytical technique for determining substance concentration in a solution. For titration consider a manual or automated system, volumetric or coulometric reagent addition and indication by a potentiometer, spectrometer, turbidometer or by the Karl Fischer method. Other features of titration to consider include burettes, reagents, concentration range, reaction time and autosamplers.Automation Supplies / AccessoriesAutomated accessories and consumables make lab processes fast, efficient and reliable. Useful automation accessories include microplate sealers, label printers and reagent reservoirs.