MLL / HRX mouse antibody (mAb) (Clone N4.4)
MLL1 (Mixed-lineage leukemia protein 1, KMT2A, TRX1, HRX1, ALL1) is a SET-domain containing histone methyltransferase specific for lysine 4 of of histone H3. It serves as a transcriptional activator for many target genes, including several HOX genes. MLL is a frequent target for translocations in acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) and mixed lineage leukemia (MLL). A key feature of MLL fusion proteins is their ability to efficiently transform hematopoietic cells into leukemia stem cells. Leukemogenic MLL translocations encode MLL fusion proteins that have lost H3 Lys4 methyltransferase activity. MLL1 is found in a complex of proteins that includes ASH2L, WDR5, DPY30 and RBBP5.
Product Details
- Cat. No.
- 39829
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Reviews
Applications
- Chromatin Immunoprecipitation (ChIP)
- Immunoprecipitation (IP)
- Western Blotting (WB)
Antibody Overview
About the company
Active Motif
Active Motif is the industry leader in developing and delivering innovative tools to enable epigenetics and gene regulation research. We are committed to providing the highest quality products and superior service & support to serve the life science, clinical and pharmaceutical/drug discovery communities. Whether you are an expert in the field of epigenetics or a researcher interested in integrating epigenetics research into your studies, Active Motif offers a comprehensive portfolio of epigenetics-related products and services and the support of our team of epigenetic experts to provide complete and innovative solutions to tackle your scientific inquiries.