MBD1 rabbit antibody (pAb)

MBD1 (methyl-CpG binding domain protein 1) functions as a mediator of the biological consequences of DNA methylation. Generally associated with the repressive chromatin state. methylation of mammalian DNA has long been recognized to play a major role in a number of cellular functions such as development and the control of gene expression. The complex series of events leading to this repressive state involve the coordinated regulation of DNA methyltransferases and two other groups of proteins called the Methyl-CpG binding proteins (MBD proteins) and the Kaiso family of proteins. The MBD family of proteins includes MeCP2, MBD1, MBD2, MBD3 and MBD4. MBD1 is recruited to both methylated and non-methylated CpGs via separate domains: the CXXC domain targets the protein to non-methylated CpGs whereas the MBD domain targets the protein to methylated CpG.