BLIMP1 / PRDM1 rabbit antibody (pAb)

BLIMP1 / PRDM1 (Beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1 Positive regulatory domain I-binding factor 1) is a DNA sequence-specific transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene, as well as other . It is required for maturation of B-lymphocytes into immunoglobin secreting plasma cells through direct repression of transcription factors such as Pax5, Bcl6, and Myc, which function in the lineage commitment and proliferation of B cells. BLIMP1 / PRDM1 contains an N-terminal SET domain and four C-terminal C2H2-type zinc-finger motifs. It is also required for effector T-cell function and for the specification of primordial germ cell lineages.