ATM phospho Ser1981 mouse antibody (mAb) (Clone 10H11.E.12), sample
ATM (Ataxia Telangiectasia Mutated) is a PI3-family protein kinase and a critical cell cycle checkpoint regulator. ATM and a related protein, ATR, play crucial roles in the maintenance of genome integrity and the response to DNA damage. Upon activation, ATM phosphorylates itself at serine 1981 and then phosphorylates a number of downstream proteins (e.g. BRCA1, CHK2, H2AX, P53, NBS1, SMC1) resulting in cell cycle arrest and the initiation of DNA damage repair. Loss of function of ATM is causal to a variety of syndromes involving increased incidence of several cancers.
Product Details
- Cat. No.
- 39530
- Type
- Primary Antibody
- Clonality
- Monoclonal
- Host
- Mouse
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Reviews
Applications
- Immunofluorescence (IF)
Antibody Overview
About the company
Active Motif
Active Motif is the industry leader in developing and delivering innovative tools to enable epigenetics and gene regulation research. We are committed to providing the highest quality products and superior service & support to serve the life science, clinical and pharmaceutical/drug discovery communities. Whether you are an expert in the field of epigenetics or a researcher interested in integrating epigenetics research into your studies, Active Motif offers a comprehensive portfolio of epigenetics-related products and services and the support of our team of epigenetic experts to provide complete and innovative solutions to tackle your scientific inquiries.