AIRE rabbit antibody (pAb)
AIRE (Autoimmune regulator, APECED, Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) is a DNA-binding transcriptional regulator that promotes the expression of tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. AIRE functions as a dimer or as a tetramer and interacts with nucleosomes, selectively interacting with histone H3 unmodified in the N-terminus through its first of two PHD domains. Defects in AIRE are a cause of autoimmune poly-endocrinopathy candidiasis ectodermal dystrophy (APECED) also known as autoimmune polyglandular syndrome type I (APS-1).
Product Details
- Cat. No.
- 61139
- Type
- Primary Antibody
- Clonality
- Polyclonal
- Host
- Rabbit
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Reviews
Applications
- Western Blotting (WB)
Antibody Overview
About the company
Active Motif
Active Motif is the industry leader in developing and delivering innovative tools to enable epigenetics and gene regulation research. We are committed to providing the highest quality products and superior service & support to serve the life science, clinical and pharmaceutical/drug discovery communities. Whether you are an expert in the field of epigenetics or a researcher interested in integrating epigenetics research into your studies, Active Motif offers a comprehensive portfolio of epigenetics-related products and services and the support of our team of epigenetic experts to provide complete and innovative solutions to tackle your scientific inquiries.