Earn your black belt with Nunchuck’s LNP making skills

The problem

Making the perfect lipid nanoparticle (LNP) takes skills. Testing flow rates and formulations one-by-one, and looking for the right sized LNP takes up time and wastes precious payloads. Scale-up often takes a whole new workflow and turns research on the next great therapy into a constant fight.

The solution

Nunchuck is the first and only platform that combines two key steps needed to make a perfectly-sized LNP – total flow rate (TFR) screening and LNP formulation. Screen 8 total TFRs in just 10 minutes to find your sweet spot fast, then jump straight into making anywhere from 0.5 to 200 mL of your LNPs.

Nunchuck’s high-efficiency microfluidic mixer design rapidly combines the aqueous and organic phases, creating LNPs with low polydispersity, narrow particle distributions, and high encapsulation efficiency. The simple workflow utilizes a bottom-up approach to LNP synthesis with high batch-to-batch reproducibility and low user-to-user variability. Nunchuck handles flow rates from 0.5 to 30 mL/min to make consistent, high-quality LNPs at any volume.

The proof

This webinar will introduce a fit-for-purpose TFR screen to make size-tunable, high-quality RNA-LNPs using cationic and ionizable lipids. Plus, explore how easy it is to dial-in the optimal TFR and scale-up to 200 mL output volume with crazy-high repeatability of size, polydispersity index, and encapsulation efficiency.

Key learning objectives

• You can tune Nunchuck to get the size LNP you need
• You can test up to 8 TFRs in 10 mins on the Nunchuck
• You can make from 0.5 mL to 200 mL LNPs on the Nunchuck

Who should attend?

• LNP research and development, formulation scientists, mRNA/LNP vaccine researchers, gene therapy researchers

Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.