What is Microfluidic Diffusional Sizing?
25 Nov 2024
Microfluidic Diffusional Sizing (MDS) is a novel solution-phase technology for measuring binding affinity and characterizing protein interactions.
Unlike traditional methods such as surface plasmon resonance (SPR) and bio-layer interferometry (BLI), MDS does not rely on surface immobilization or purification, making it possible to easily work with a wide variety of targets across all sample types — from small peptides to large protein complexes, and in simple buffers to complex biofluids like plasma or serum.
Explore how MDS provides a predictable and direct measurement: the molecular size, or hydrodynamic radius (Rh), which allows scientists to determine binding affinity and calibration-free concentration or binding stoichiometry — all at once.
About the company
Fluidic Sciences
Fluidic Sciences is dedicated to advancing the study of protein interactions, recognizing their critical role in biological processes. Guided by the belief that “DNA is the script, but proteins are the actors,” the company develops in-solution technologies and instruments that eliminate immobilization complexities, enabling accurate and efficient analysis in native environments.
By combining biophysical expertise with innovative digital tools, Fluidic Sciences provides researchers with robust solutions to uncover the intricacies of protein behavior, driving progress in biomedical research and discovery.