Revolutionizing plasma cell disorder diagnostics with mass spectrometry

30 Sept 2024
Revolutionizing plasma cell disorder diagnostics with mass spectrometry

Angela Dispenzieri, MD, Professor of Medicine, Division of Hematology, Department of Internal Medicine, Mayo Clinic, discusses the use of mass spectrometry for plasma cell disorder diagnostics. Mass spectrometry of monoclonal proteins is transforming plasma cell disorder diagnostics by enhancing sensitivity and specificity beyond traditional immunofixation. This innovative approach provides detailed fingerprinting of myeloma and amyloid proteins, crucial in the era of therapeutic monoclonal antibodies. With the ability to accurately identify and monitor proteins, mass spectrometry offers revolutionary potential in diagnosing and managing plasma cell disorders, promising more precise treatment outcomes for patients.

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HematologyIn Haematology / Hematology, complete blood cell counts (or full blood counts) are obtained using automated blood count analyzers to enumerate blood cell types.  Hematology also encompasses haemostasis and coagulation, thrombophilia and hemophilia, plasma viscosity and ESR analysis, hemoglobinopathies, cell morphology and haematinic measurement.MyelomaMultiple Myeloma