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Visualizing NK cell-tumor interactions: A dynamic approach to spheroid-based tumor killing assays using Celloger Pro
3 Sept 2025In this application note, CURIOSIS investigates NK cell-mediated cytotoxicity in a U-2OS spheroid model using real-time imaging. This was achieved using the Celloger® Pro live-cell imaging system, which enabled continuous, non-invasive visualization of immune-tumor interactions. These findings highlight the value of real-time imaging in assessing immune effector functions and support the use of spheroid-based assays as a reliable platform for immunotherapy research.
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Celloger® Pro, Automated Live Cell Imaging System from Curiosis
CURIOSISWith its streamlined workflow and versatile capabilities, Celloger® Pro is a valuable tool for researchers seeking efficient, accurate, and cost-effective cellular analysis.
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Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Live Cell ImagingLive cell imaging is the study of living cells using microscopes and high-content imaging systems. This technique provides in-depth insight into fast and complex biological processes, by allowing dynamic imaging of living cells instead of acquiring an individual image at a single point in time.CytotoxicityCytotoxicity assays measure the toxic effects of substances on cells, often used in drug testing and environmental studies. These tests are crucial in determining the safety of chemicals and pharmaceutical compounds. Explore cytotoxicity testing tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.