Utilizing the Labcyte Echo Liquid Handler and the BMG PHERAstar FS to Miniaturize and Automate a Series of G9a Histone Methyltransferase Assays
3 Sept 2017Epigenetic processes are attracting considerable attention in drug discovery as their fundamental roles in the regulation of normal cell development and contributions to disease states become more clearly defined. Histone methyltransferases (HMTs) are high interest drug targets as histone methylation is linked to certain disease states, including a wide variety of cancer types. This application note demonstrates the utility of the Echo series of acoustic liquid handlers toward developing G9a histone methyltransferase (HMT) assays in a parallel, streamlined and automated workflow.
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Echo® 500 Series Liquid Handlers
The Echo® liquid handler revolutionizes liquid handling with acoustic energy. Sound waves eject precisely sized droplets from a source onto a microplate, slide or other surface suspended above the source. This product does not use tips, pin tools or nozzles—completely eliminating contact between the instrument and the liquid. The Echo liquid handler provides powerful benefits: Tipless transfer, resulting in dramatic cost savings Improved information about sample integrity and improved transfer quality through measurement of DMSO hydration level Elimination of the need for calibration through Dynamic Fluid Analysis™ technology, a patented Labcyte process Elimination of cross-contamination, carryover or leachates through non-contact transfer Accurate, precise movement of nanoliter-scale quantities, enabling assay miniaturization and further reducing costs Better results through direct dilution of compounds, an improvement over serial dilution methods Greatly simplified assay development and dilution processes through the flexibility to transfer any volume of liquid from any well to any other well