ResourceLife Sciences
Utility of Automated Drug Transport Assays in 96-Well Format, using Permeable Support Systems
10 Sept 2014To meet the demands for higher throughput and reduced processing time, this poster presents an automated drug transport assay using either Caco-2 or MDCKII/MDR1 cells in 96-well Permeable Supports.
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24 mm Transwell® with 8.0 µm Pore Polycarbonate Membrane Insert, Sterile
Corning Life Sciences(This is the suggested replacement for 3403) 10 µm thick translucent polycarbonate membrane Treated for optimal cell attachment Packaged 6 inserts in a 6 well plate, 4 plates per case Membrane must be stained for cell visibility
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Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Drug DosageDosage is the size or frequency of the administration of a drug. Determination of the dosage of a drug is critical in pharmaceutical development to ensure the optimum balance between efficacy and toxicity.High ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.Assay DevelopmentThe process of proving an assay to be sensitive with respect to the target is known as assay development. The assay should be able to characterize novel compounds and measure the potency of these compounds against a validated biological target.ADMEPharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.