ResourceLife Sciences
Using Bio-Plex Phosphoprotein Assays to Study EGFR Signaling in Human Patient-Derived Xenografts Treated with Cetuximab
9 Sept 2012Cetuximab has been used to treat many advanced cancers, but is only effective in a fraction of patients. In this application note by Bio-Rad the Bio-Plex phosphoprotein assays were used to demonstrate that the effectiveness of cetuximab is not determined solely by its ability to inhibit EGFR activation.
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Bio-Plex® 3D Suspension Array System
Bio-RadIncludes Bio-Plex 3D Suspension Array System, xPONENT 4.0 acquisition software, PC, Calibration Reagents, Verification Reagents, Bio-Plex Manager 6.0, Desktop License.
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ADME-ToxicologyADME-toxicology (ADME-Tox) studies are used in pharmacology and pharmacokinetics to assess the activity/toxicity of drugs <i>in vivo</i> or <i>in vitro</i>. Find bioassays for absorption, distribution, metabolism, and excretion of drug molecules including cytotoxicity, transporter/permeability, metabolism and activity assays as well as hepatocytes and cell lines for ADME. Find the best ADME-toxicology products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.Cancer ResearchAlthough cancer is often referred to as a single condition, it actually consists of more than 100 different diseases. Microscopy, mass spectrometry, high throughput sequencing and flow cytometry are some of the most common techniques employed in cancer research labs.Cell ProliferationCell proliferation refers to the process by which cells divide and multiply. This is a key concept in cancer research, tissue regeneration, and immunology studies. Explore cell proliferation tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Tumor GrowthXenograftEGFR