ResourceLife Sciences
Use of upcyte® Human Hepatocytes for the Prediction of Hepatotoxicity
12 Apr 2015upcyte® Human Hepatocytes are unique in that they are differentiated cells that can be generated in vast numbers. Both features are essential for a better prediction of hepatotoxicity than cell lines, whilst addressing the demand for higher throughput screening. This application note shows that upcyte® Human Hepatocytes are an excellent alternative to cell lines that are traditionally used to detect hepatotoxins.
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Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell-Based AssaysCell-based assays are used to monitor the presence, quantity and activities of a desired cellular analyte including drug molecules or biomarkers. This can reveal information on cell health (apoptosis, cytotoxicity, viability and proliferation assays), cell metabolism, cell migration and cell signaling mechanisms. Find the best cell-based assay products, kits and equipment with our peer reviewed product directory: compare products, check customer reviews and receiving pricing direct from manufacturers.HepatotoxicityHepatocytes