Use of Physiologically-Based Pharmacokinetic Modeling (PBPK) in Conjunction with CellCiphr HCS to Predict Compound Safety Thresholds and Improve Lead Optimization

Cloe® PK - Pharmacokinetic prediction using PBPK modelling Cloe® PK is an innovative software system that uses PBPK modelling for pharmacokinetic prediction. By integrating physicochemical and ADME screening data, Cloe® PK can predict the levels and duration of drugs in blood, major tissues and organs. Human intestinal absorption model Cloe® Predict Human Intestinal Absorption Model is a reliable physiological model which uses a combination of solubility and Caco-2 permeability data for the prediction of human intestinal absorption. Auto QSAR and automation of laboratory workflow The Cyprotex Discovery Bus is a novel and powerful software platform designed to enhance efficiency in drug discovery by automating human decision making and information handling using intelligent workflow. Applications include auto QSAR and automation of laboratory workflow processes.