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Understand the mechanics of single molecules with the ForceRobot 400 BioAFM

Bruker Nano Surfaces and Metrology
22 Jun 2023

Forces play a crucial role in molecular mechanisms, such as recognition, response, and signaling. In this application note, explore how Bruker’s new ForceRobot® 400 BioAFM incorporates a number of force spectroscopy innovations to measure forces at the single-molecule level. Furthermore, learn how this new technology enables the quantification of the mechanical strength of individual molecular bonds and the characterization of the force-dependent properties of molecular interactions and biomolecular complexes.

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ForceRobot 400

Bruker Nano Surfaces and Metrology

The ForceRobot ® 400 BioAFM incorporates a number of unique force spectroscopy innovations to measure forces at the single-molecule level. As forces play a crucial role in molecular mechanisms, such as recognition and signaling, this BioAFM is uniquely suited for emerging life science research. It enables the quantification of the mechanical strength of individual molecular bonds and the characterization of the force-dependent properties of molecular interactions and biomolecular complexes

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Mechanical TestingMechanical testing explores the elastic and inelastic nature of a material when force is applied. A mechanical test shows whether a material is suitable for its intended application by measuring hardness, tensile strength, elongation, elasticity, and fatigue limit.Molecular BiologyMolecular biology is the branch of biology that focuses on the molecular mechanisms that underlie cellular functions. It involves studying DNA, RNA, and proteins to understand gene expression, replication, and regulation. Molecular biology is fundamental to biotechnology, medicine, and genetic research. Explore molecular biology products in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.SpectroscopySpectroscopy is a technique that analyzes the interaction of light with matter to study molecular properties, concentrations, and structural information. Widely used in chemical, pharmaceutical, and environmental analysis, spectroscopy offers insights into molecular composition and helps identify unknown compounds. It plays a key role in quality control, research, and diagnostics. Browse our peer-reviewed product directory to compare spectroscopy tools, read reviews, and get prices directly from manufacturers.Molecular DiagnosticsMolecular diagnostics use an individual’s genetic code and gene expression to diagnose and monitor diseases. The technique is used increasingly in the field of infectious diseases and oncology, as well as areas such as coagulation, HLA typing and pharmacogenomics. Molecular diagnostics plays a pivotal role in personalized medicine.

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Understand the mechanics of single molecules with the ForceRobot 400 BioAFM