ResourceSpectroscopy

Uncover new dimensions of isotope ratio analysis with Thermo Scientific Orbitrap MS technology

6 Jun 2025

Isotope ratio mass spectrometry (IRMS) is a powerful tool for determining subtle isotopic variations within a sample and works by breaking down complex molecules in simple gases. This technique can provide unique insights however important intramolecular isotopic information is often lost.

Explore a new, comprehensive approach to IRMS using electrospray ionization (ESI). Thermo Scientific™ Orbitrap™ MS technology gives access to a wide range of isotopic information from a variety of polar compounds in liquid samples. In contrast to classical IRMS methods, Thermo Scientific™ Orbitrap Exploris™ Isotope Solutions enable the calculation of isotope ratios directly from the relative abundances of the compounds isotopologues, measured as intact molecular ions.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Isotope Ratio Mass Spectrometry
Uncover new dimensions of isotope ratio analysis with Thermo Scientific Orbitrap MS technology