Total Organic Carbon Determination According to USP 643

20 Jul 2016

This application note describes the determination of impurities in purified water and water for injections according to the US Pharmacopeia Total Organic Carbon (TOC) parameter. Shimadzu offers two systems that are ideally suitable for TOC determination in ultrapure water. Both types of instrument with their different oxidation methods can be used for TOC determination in accordance with the new United States Pharmacopeia USP 643.

TOC-L Total Organic Carbon Analyzer

Shimadzu Corporation

  Consisting of four models, including PC-controlled and standalone versions, the TOC-L uses Shimadzu’s 680° C combustion catalytic oxidation method to efficiently analyze all organic compounds. It features automatic sample acidification and sparging, as well as an automatic dilution function that reduces sample salinity, acidity and alkalinity. This significantly extends the use of catalysts and combustion tubes. The TOC-L Series features variable syringe sizes when the sample volume is limited. High-precision mass flow controllers ensure uninterrupted carrier gas for accurate analysis. A zero-maintenance Peltier cooler used for maximum water vapor removal ensures accurate analysis. In addition, an on-board air purifier may eliminate the need for high-purity air during testing. The optional salt kits permit 12 times more salt to be analyzed before maintenance is required. The ASI-L autosampler can use three different vial sizes for various applications, while the smaller OCT-L autosampler can use any vial size for up to 8 or 16 samples. TOC-L models can accept particulates up to 500 microns or 800 microns with the optional particulate kit. For larger particles, solids, soils and sludge, the SSM-5000 is the ideal solution. The TNM-L can be added for simultaneous TOC and Total Nitrogen analyses without increasing the size of the footprint.  

(13)

Links

Tags

Water PurificationThere are a number of water purification methods available to remove contamination from laboratory water. These systems include demineralization, reverse osmosis, filtration and ultrafiltration. A combination of methods is sometimes necessary to achieve purified water suitable for use in experiments.Ultrapure WaterUltrapure water is the highest purity water and contains the lowest levels of organic and inorganic contaminants, particulates and microorganisms.Water AnalysisAnalytical methods used to test the purity of drinking water include determining the level of contaminants abides to the level set by the Environmental Protection Agency (EPA).Trace Level ImpuritiesTrace level impurities refer to low concentrations of unwanted substances found in chemicals, pharmaceuticals, and other products. Detecting and removing these impurities is crucial for product safety and regulatory compliance. Explore trace impurity analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.TOC MonitoringUSP Method