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The use of PATROL UPLC Process Analysis System for Continuous Flow Chemistry Processes in a Pharmaceutical Company

8 Nov 2017

This work discusses the utility of UltraPerformance Liquid Chromatography (UPLC)-based Process Analytical Technology (PAT) systems for monitoring continuous flow reactions locally in near real time. This technology provides rich process understanding, which facilitates rapid and informed decision making.

PATROL UPLC Process Analysis System

Waters

Take control of your bottom line – get a better understanding of your process and your product. For the first time, bring automation and UPLC together for direct online connection to your process with Real-TIME LC. The PATROL UPLC Process Analysis System is specifically designed for in-process analysis, delivering simultaneous qualitative and quantitative information and allowing you to dynamically adjust and control your process. Continuous system uptime and remote access from any location gives you confidence that your process is under control and within design space. Automated or walk-up sample entry - it's easy to run Fully automated operation or accessed via an intuitive touch-screen interface, for simplified walk-up and single press-button interaction. Analytical procedures are fully automated from sample to results, allowing more agile decisions to move your production process forward. Designed for direct closed-loop feedback to a distributed control system (DCS) or laboratory information management system (LIMS). Designed and engineered for continuous operation Powered by proven UPLC Technology. From system and sample thermal management, to muilt-buffer and multi-column management, to data processing and reporting, the functionality of each module of the PATROL UPLC Process Analysis System has been purposefully integrated to deliver optimal performance. Waters' best-in-class columns assure consistency of your results with batch-to-batch and column-to-column reproducibility. Engineered to enable fast and simple replacement of modular components for reduced downtime when maintenance is required. On-board diagnostics improve uptime and reliability Incorporates automated and comprehensive diagnostics tools with Connections INSIGHT Remote Services, which monitors the operational parameters of the system, and provides alerts if its performance is outside set user limits. The system provides predictive maintenance recommendations via automated visual, email, and mobile device alerts, so you can plan for downtime to minimize impact to your production line. Water's proven commitment to best-in-class support services, technical knowledge, and quick resolution of system issues helps you protect and enhance the value of your investment in Waters technologies.

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Software PlatformsSoftware platforms are useful for various stages of laboratory experiments from data collection to data storage and processing. For instance lab software is available for system control, data management, data analysis and qualification / validation.ChromatographyChromatography is a powerful technique used to separate and analyze components of mixtures based on their chemical properties. It is widely used in fields like biochemistry, pharmaceuticals, and environmental analysis. By exploiting differences in the interaction of substances with a stationary phase and a mobile phase, chromatography enables precise purification and quantification of compounds. Whether you're working with complex biological samples or industrial chemicals, chromatography is essential for obtaining high-quality results. Browse our peer-reviewed product directory to find the best chromatography systems, compare products, read customer reviews, and get pricing directly from manufacturers.Flow ChemistryFlow chemistry describes a chemical reaction being carried out continuously rather than in a batch process. The reagents are pumped through a pipe and forced together at a mixing junction, where they are allowed to combine until the reaction is stopped.PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.
The use of PATROL UPLC Process Analysis System for Continuous Flow Chemistry Processes in a Pharmaceutical Company