ResourceSpectroscopy

The Importance of High Glass Quality for Detecting Low Concentrations of Analytes

15 Nov 2018

In this application note, drugs (e.g. Doxepin, Clomipramin, Bromperidol (containing trisubstituted N-atoms = tertiary amines and other TCA´s) have been investigated in serum in order to see the effects of certain glass qualities. The results are reported by reproducibility data using different types of 2 mL autosampler glass vials.

Thermo Scientific™ UltiMate™ 3000 UHPLC system

Thermo Fisher Scientific

  The Thermo Scientific™ UltiMate™ 3000 HPLC system offers UHPLC compatibility across all modules, ensuring maximum performance. Covering flows from 20 nL/min to 10 mL/min and offering a wide range of pumping, sampling, and detection modules, the UltiMate 3000 series provides solutions for all your chromatography needs. UltiMate 3000 HPLC system Features & Benefits:   UHPLC design for all nano, standard analytical, and RSLC systems. 620 bar maximum pressure for basic and standard analytical systems—setting a new benchmark in HPLC. x2 Dual Systems form a unique platform for routine analysis, increased productivity solutions, and advanced chromatographic techniques. Systems are controlled using Thermo Scientific™ Chromeleon™ Chromatography Data System software—providing Intelligent Functionality and Operational Simplicity™. Systems are offered with Thermo Scientific™ Viper™ and Thermo Scientific™ nanoViper™ fitting systems—fingertight, zero-dead-volume connections even at UHPLC pressures.

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Thermo Scientific™ Q Exactive™ GC Orbitrap™ GC-MS/MS System

Thermo Fisher Scientific

The Thermo Scientific™ Q Exactive™ GC system is the first-ever combination of high resolution gas chromatography with high-resolution/accurate-mass (HR/AM) Orbitrap detection for the most comprehensive sample characterization. This easy-to-use system provides the most comprehensive characterization of samples in a single analysis for the highest confidence in compound discovery, identification, and quantitation. Building upon the flexible modularity of the Thermo Scientific™ TRACE™ 1300 Series GC, including user-exchangeable injectors and detectors, the Q Exactive GC system has the quantitative power of a GC triple quadrupole MS combined with the high precision, full scan high-resolution/accurate-mass capability that only Orbitrap technology can offer.   Key Features: Advanced quadrupole technology (AQT) for high transmission of selected masses Resolving power up to 120,000 at m/z 200 Part-per-trillion-level sensitivity Thermo Scientific™ Extractabrite™ ion source for robust, rugged electron impact (EI) and chemical ionization (CI) performance Curved linear C-trap for precise ion injection HCD collision cell for higher energy collisional dissociation provides MS/MS ion characterization Intelligent identification software elucidates the nature of each injected sample. Applications: Untargeted and targeted metabolomics Food and beverage Industrial analyses Environmental Pharmaceutical Clinical and toxicology

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Thermo Scientific™ Hypersil GOLD™ C18 Selectivity LC Columns

Thermo Fisher Scientific

Achieve exceptional peak shape and resolution for your HPLC and LC/MS applications with Thermo Scientific™ Hypersil GOLD™ HPLC columns. These endcapped, ultrapure, silica-based columns deliver significant reduction in peak tailing using generic gradients with C18 selectivity. With their excellent resolution, efficiency, and sensitivity, Hypersil GOLD columns give you confidence in the accuracy and quality of your analytical data.

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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.GlassGlass is an amorphous solid (non-crystalline) typically made up of silica and silicon dioxide. This transparent solid has many applications, from window panes to optical lenses for microscopes.PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.