ResourceSpectroscopy
Successful parental formulations by preventing crystallization
25 Mar 2020This application note provides a case study on how the Crystal16 and the Crystalline instrument can be used to produce successful parental formulations by preventing crystallization.
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Crystalline PV/RR
Technobis Crystallization SystemsAccess crystallization and formulation information at mL scale with the new Crystalline PV/RR
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X-ray CrystallographyX-ray crystallography is an analytical technique used to determine the arrangement of atoms in a crystal. Monochromatic x-rays are produced from a synchrotron or x-ray generator. An x-ray crystallography system uses a detector to measure the x-ray diffraction from the crystal. The information is used to generate a 3D image of the crystal.Protein CrystallographyProtein crystallization is the process of crystallizing purified proteins for 3D structure analysis by x-ray crystallography. The main methods of protein crystallization include sitting drop, hanging drop and microbatch. It is important to control parameters such as pH, temperature and concentration. Following crystallization, detectors and software are used for data collection and analysis.FormulationFormulation is the process of combining active pharmaceutical ingredients with excipients to produce a drug which is both stable and active.CrystallizationCrystallographyProtein Stability