ResourceDrug discovery > Lead Discovery
Sub-Nanogram Level Intact Monoclonal Antibody Quantitation by LC/Q-TOF
27 Jan 2018Quantifying biopharmaceuticals by studying the intact protein levels avoids limitations seen in the more common targeted multiple reaction monitoring techniques, but can face problems with analytical sensitivity and reproducibility. Using the latest developments in chromatography and the high performance Agilent 6545XT AdvanceBio LC/Q-TOF, this study establishes a highly sensitive and reproducible quantitative analytical method that spans an impressive linear dynamic range.
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Agilent 1290 Infinity III Multisampler
Agilent TechnologiesThe 1290 Infinity III Multisampler is a multipurpose autosampler that handles vials and microplates. Injecting at pressures up to 1300 bar, the Multisampler is a compact module with a capacity of up to 6,144 samples, all within the footprint of an Agilent LC stack.
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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.Monoclonal AntibodiesMonoclonal antibodies (mAbs) are lab-made molecules that can bind to specific antigens on cells, making them highly effective in treating cancers, autoimmune diseases, and infections. These targeted therapies are transforming the treatment landscape for many conditions. Browse our peer-reviewed product directory to find monoclonal antibodies for research and clinical applications; compare products, check reviews, and get pricing directly from manufacturers.Quantitative AnalysesQuantitative analyses involve measuring the amount or concentration of a substance in a sample using analytical techniques. These analyses are essential in fields like chemistry, biology, and environmental science. Explore quantitative analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.