ResourceLife Sciences
Studying Paneth Cell Differentiation Using the Tecnai with iCorr
9 Apr 2015Intestinal Paneth cells, originally identified as an anti-microbial secreting cell population, have emerged as critical modulators of active cycling intestinal stem cells, supplying critical molecular cues that influence stem cell behavior. In a study to elucidate factors that influence Paneth cell differentiation, Nick Smith and Melissa Wong (OHSU) used the Tecnai with iCorr to perform correlative light and electron microscopy imaging of mouse intestinal tissue to evaluate the full differentiation of the Paneth cell population.
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Light MicroscopyLight microscopes or optical microscopes are used to visualize microscale objects under magnification, including cells, clinical specimens and materials. Lab equipment for light microscopy includes confocal microscopes, fluorescence microscopes, zoom and stereo microscopes. Microscope slides and imaging reagents are available for visualizing samples, as well as various microscope stages and incubators for large or temperature-sensitive samples. Find the best light microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Electron MicroscopyElectron microscopes (EM) are used to create high-resolution images of samples at the nanoscale by means of an accelerated beam of electrons as a source of illumination. Types of electron microscope include scanning electron microscopes (SEM), transmission electron microscopes (TEM), scanning transmission electron microscopes (STEM) and cryo-electron microscopes. Focused ion beam (FIB) microscopes are useful for modifying or milling a sample surface with nanometer precision, as well as imaging. Find the best electron microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Stem Cell ResearchStem cells have the ability to produce identical daughter cells as well as progeny, which commit and differentiate. Stem cell research has exciting prospects of biomedical applications in cellular disease modeling, pharmaceutical screening, and regenerative medicine.