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Stearates Verification Using a Handheld Raman Analyzer

Thermo Fisher Scientific
10 Jun 2018

Magnesium stearate, calcium stearate, and zinc stearate are frequently used in the pharmaceutical industry as lubricants for capsules and tablets, but share a similar chemical structure which makes them challenging to verify. In this application note, various stearates were successfully identified by utilizing a customizable principle component analysis (PCA) method on the Thermo ScientificTM TruScanTM RM Handheld Raman Analyzer.

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The Thermo Scientific™ TruScan™ RM Handheld Raman Analyzer delivers reliable material identity verification through sealed packaging in seconds, right at the point-of-need. With the Thermo Scientific TruTools™ embedded chemometrics package, users can build advanced, customized qualitative and quantitative methods for complex material analysis problems.

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Raman SpectroscopyRaman spectroscopy is used to discern the vibrational and rotational states of molecules and hence the chemical composition of a sample by measuring the inelastic scattering of monochromatic light. Explore a range of Raman spectrometers, including handheld/portable Raman spectrometers for QC/QA labs and in situ spectrometers for processes. Conduct Raman imaging for microanalysis of mixed samples using a Raman microscope. Raman spectrographs are also available. Find the best Raman spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.SpectroscopySpectroscopy is a technique that analyzes the interaction of light with matter to study molecular properties, concentrations, and structural information. Widely used in chemical, pharmaceutical, and environmental analysis, spectroscopy offers insights into molecular composition and helps identify unknown compounds. It plays a key role in quality control, research, and diagnostics. Browse our peer-reviewed product directory to compare spectroscopy tools, read reviews, and get prices directly from manufacturers.

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Stearates Verification Using a Handheld Raman Analyzer