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Small-Molecule Cocktail for Rapid Maturation of Human Neurons

BrainXell
7 Aug 2018

A major application of neurons derived from human induced pluripotent stem cells (iPSCs) is to model neurological or psychiatric diseases for use as a drug discovery platform. Most phenotypes of neurological and psychiatric diseases arise in mature neurons. However, human iPSCs-derived neurons can take 1-3 months to reach full functional maturation, and yet manipulating the neuronal cultures for even 2 weeks in
384-well plates is cumbersome. Therefore, the substantial time required for achieving maturation is a severe hurdle for taking full advantage of human neurons as drug discovery platforms.

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BrainFast Neuronal Maturation Supplement

BrainXell

BrainXell’s BrainFast Neuronal Maturation Supplement is a proprietary combination of small molecules that is used to accelerate the differentiation of neural progenitor cells to mature neurons. It is effective with a variety of neuronal subtypes including, but not limited to, motor neurons, glutamatergic neurons, and GABAergic neurons

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Fluorescence SpectroscopyFluorometers and spectrofluorometers (also called fluorescence spectrometers) are used to measure the intensity and wavelength of fluorescent light emitted from a sample after excitation by illumination. Spectrofluorometers utilize monochromators to select the desired wavelengths, whereas filter fluorometers employ a set of filters. Spectrofluorometers for measuring steady-state fluorescence and lifetime fluorescence (or time-resolved fluorescence) are available, as well as fluorescence microscopes and microplate readers. Find the best fluorescence spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cell Lines Stem Cells and Primary CellsPrimary cell cultures, established cell lines and stem cells are vital for <i>in vitro</i> and <i>ex vivo</i> experimentation. High-quality cells, optimized for your applications, alongside optimized cell substrates, growth medium and supplements, are critical for experimental success. Explore a range of cells suitable for your applications, including isogenic cell lines, competent cells, induced pluripotent stem cell (iPSC)-derived cell lines, fungal/bacterial/mammalian cell lines, stem cells and cancer cell lines. Find the best cells for your research in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.NeuronsNeurons are the fundamental units of the brain and nervous system, involved in transmitting information. Understanding neuron function is critical in neurobiology, neuroscience, and neurodegenerative disease research. Explore neuron research tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.hiPS Cell LinesPhenotypic ScreeningPhenotypic screening assesses cellular responses to compounds, enabling drug discovery and target identification. This technique is pivotal in finding effective treatments for complex diseases. Discover phenotypic screening platforms and tools with peer-reviewed comparisons and pricing in our directory.

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Small-Molecule Cocktail for Rapid Maturation of Human Neurons