ResourceLife Sciences
Single domain antibody development from ProSci
7 Dec 2023Single domain antibodies (sdAbs), also known as VHH antibodies, are recombinant antibodies comprised of the binding domain from heavy chain only camelid antibodies. Due to their small size, ~15kDa, and their longer and structurally unique Complementarity Determining Region 3 (CDR3 region), they target unique epitopes inaccessible by conventional antibodies. This application note explores ProSci’s single domain antibody development service that offers two different packages: Premier – Immunization through library construction, and Pro – Immunization through final clones, as well as customized packages. The current catalog of ProSci sdAbs also includes antibodies to select immune checkpoint targets and SARS-CoV-2 spike glycoprotein S1 and S2 domains.
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