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Separation of synthetic benzodiazepines by SPE and LC-MS/MS

Phenomenex Inc
15 Jun 2023

In this application note, Phenomenex focuses on tracking and detecting synthetic benzodiazepines using effective LC-MS/MS techniques. The study quantifies 14 compounds in a urine matrix with high-sensitivity using fast LC analysis. The panel includes 13 "synthetic" benzodiazepines, and Alprazolam is added for necessary differentiation. Strata®-X-Drug B Plus is chosen as the ideal SPE plate, and a Kinetex® Biphenyl LC column is used for chromatographic separation.

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Strata-X-Drug B Plus

Phenomenex Inc

Perform your enzyme hydrolysis in a 96-well plate with Solvent Shielding Technology™ to hold solvent for 6 hours or more! •    Save Time-Eliminate transfer steps •    Save Money-Decrease consumables and solvents cost •    Simplify Your Method-No equilibration or condition required  

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drug TestingIt is essential to test the efficacy and toxicity of drugs at every stage of their development to ensure that a pharmaceutical product is fit for purpose and safe for use before reaching the stage of mass production and distribution.BenzodiazepinesSolid Phase Extraction (SPE)Solid phase extraction (SPE) is a sample preparation technique used to separate and concentrate analytes from complex mixtures. It is widely used in environmental, pharmaceutical, and clinical analysis. SPE provides higher sensitivity and selectivity compared to traditional liquid-liquid extraction methods, making it essential for accurate and reproducible results. Explore SPE tools and systems in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.

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