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Sensitive detection of low-level byproducts in a small molecule reaction by the Agilent 1260 Infinity II Prime online LC/MS system

Agilent Technologies
18 Jan 2023

In the production process of modern small-molecule pharmaceuticals, it is of crucial importance not only to control the educts and products through the course of the reaction, but also the possibly occurring impurities. Such impurities can pollute the valuable active pharmaceutical ingredient (API). This would make it necessary to introduce additional costly purification steps into the production. This application note demonstrates the online monitoring of a chemical reaction with an occurring byproduct by means of the Agilent 1260 Infinity II Prime Online LC/MS system, including a mass spectrometer, the Agilent LC/MSD iQ single quadrupole. The inclusion of the MSD iQ offers additional sensitivity and selectivity for the identification of low-level impurities for more reliable control of chemical reactions.

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Agilent 1260 Infinity II Prime LC System

Agilent Technologies

The 1260 Infinity II Prime LC is a versatile HPLC offering the highest functionality and operational convenience for analytical HPLC and entry-level quaternary UHPLC at pressures up to 800 bar and for flow rates up to 5 mL/min. This versatile HPLC system is a perfect front end for your MS system. 

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Combinatorial ChemistryCombinatorial chemistry, also known as combichem, is a technique used in drug discovery to create libraries of structurally related compounds. A library is generated by synthesis with a chemical reactor system or by computer-based modeling of compound combinations. When undertaking combinatorial chemistry consider reagents, buffers, resins and standards.Chem / BioinformaticsCheminformatics and bioinformatics are computational techniques used in chemistry and biology, respectively, for data acquisition, processing and storage. Cheminformatics focuses on compound information, whereas bioinformatics is mainly applied to analysis and modeling of genomics, genetic and sequencing information. Hardware and software is available for data acquisition, analysis, management and storage.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Development SoftwareComputational techniques used in both the chemistry and biology aspects of drug development, for data acquisition, data analysis, processing and storage. Software is used for analysis of ADME results, toxicology, clinical trials and regulatory processes. Software PlatformsSoftware platforms are useful for various stages of laboratory experiments from data collection to data storage and processing. For instance lab software is available for system control, data management, data analysis and qualification / validation.PurificationPurification techniques are essential for isolating compounds of interest from complex mixtures, such as proteins, nucleic acids, and chemicals. These techniques are critical in biochemistry, drug development, and environmental studies. Explore purification systems in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Reaction MonitoringPharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.

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