ResourceLife Sciences
Screening of copolymer nanodiscs with multi-parameter stability characterization on the Prometheus Panta
9 Oct 2024Cryogenic electron microscopy (cryo-EM) has enabled atomic-level structure determination of many complex proteins that were not previously achievable with X-ray crystallography or nuclear magnetic resonance (NMR). Explore how the application of dynamic light scattering (DLS) and nano differential scanning fluorimetry (nanoDSF), provided by the Prometheus Panta, helps membrane protein structural biologists rapidly find the best copolymers for their synthetic nanodiscs, ensuring the highest atomic resolution for cryo-EM structures.
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Particle CharacterizationParticle characterization instruments are used to determine particle size distribution, shape, surface area, zeta potential, density and porosity of particles and materials. Multiple tecchniques are available for determining particle size, shape and count including dynamic light scattering (DLS), laser diffraction, electrozone (Coulter technique), imaging particle analysis and single particle optical sensing. Determine the density of your material with a gas pycnometer or examine its surface area and porosity with gas adsorption analyzers and mercury porosimeters. Find the best particle characterization instruments in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Electron MicroscopyElectron microscopes (EM) are used to create high-resolution images of samples at the nanoscale by means of an accelerated beam of electrons as a source of illumination. Types of electron microscope include scanning electron microscopes (SEM), transmission electron microscopes (TEM), scanning transmission electron microscopes (STEM) and cryo-electron microscopes. Focused ion beam (FIB) microscopes are useful for modifying or milling a sample surface with nanometer precision, as well as imaging. Find the best electron microscopes in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Cryo-electron microscopy