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Screening Method for 122 Acidic, Neutral and Basic Drug Analytes in Plasma, Serum, Urine, or Tissue by LC-MS/MS

UCT, Inc.
13 Feb 2015

With the use of LC/MS/MS and full screen (QTrap methodology) the complete detection of both illicit and prescribed drugs can be accomplished easily with a simple solid phase extraction preparation. This application note shows the development of a rapid, highly sensitive qualitative method for the analysis of acidic, neutral, and basic compounds in biological fluids using Clean Screen XCEL® I solid phase extraction columns. The sample preparation is minimized while efficiently extracting a large group of representative compounds.

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Clean Screen® XCEL Solid Phase Extraction Columns

UCT, Inc.

The Clean Screen® XCEL Solid Phase Extraction Columns are a line of sample prep phases designed to reduce the number of steps in the extraction, and therefore the amount of time and solvent necessary to complete the sample cleanup. Further advantages include reduced sample size and improved cleanliness and recovery. The Xcel I column will extract a wide array of basic drugs including benzodiazepines and opiates. The Xcel II column is designed solely for the extraction of the THC metabolite.

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Solid-Phase ExtractionSolid-phase extraction (SPE) is used for clean-up, extraction and concentration of semi-volatile or non-volatile analytes from complex mixtures including blood, urine and food samples. Multiple formats are available for conducting SPE, including prepacked SPE cartridges, disks and microplates, as well as SPE sorbent powders for manual packing. SPE systems can be used to automate the process and extract multiple samples at once. Solid-phase microextraction (SPME) and supported liquid extraction (SLE) products are also available in the same formats. Find the best SPE, SLE and SPME equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Toxicology / Drugs of Abuse TestingToxicology and Drugs of Abuse Testing is the investigation into toxic and illegal substances found at the scene of a crime or from a suspect and / or victim associated with a scene of a crime. Analyzers, immunoassays and drugs of abuse test kits and presumptive test kits are an essential aspect of toxicology investigation.Forensic ToxicologyForensic toxicology is used to determine cause of death, drug use and contaminations. Toxicological evaluations are commonly used in analytical chemistry, clinical, life sciences and forensics.Toxicology Screening

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Screening Method for 122 Acidic, Neutral and Basic Drug Analytes in Plasma, Serum, Urine, or Tissue by LC-MS/MS