ResourceSpectroscopy
Screening and semi-quantitation of 212 fentanyl analog compounds by the Orbitrap Exploris 120 mass spectrometer
12 Nov 2023In this application note from Thermo Fisher Scientific, explore a method for fentanyl screening and semi-quantitation in urine for all 212 fentanyl analog compounds contained in the Fentanyl Analog Screening (FAS) Kit and Emergent Panels. Sample preparation includes simple 20× dilution in water, quantitation by full high-resolution accurate mass (HRAM) MS scan, and confident confirmation by retention time, accurate m/z, isotope pattern matching to calculated theoretical isotope pattern, and matching experimentally collected MS2 spectra to an in-house MS2 spectral library.
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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.