Scaling with organoids: Implementing patient-derived organoid models in high-throughput workflows

7 Aug 2025

Producing patient-derived organoids (PDOs) at scale has become a major bottleneck in adopting these models for high-throughput and repeat-use applications such as pooled CRISPR screening, hit-to-lead screening, and compound screening. Traditional culture methods are slow, labor-intensive, and often yield inconsistent organoid models, making it difficult to meet the demands of these applications.

In this eBook, we explore these challenges in depth and share proven strategies to help you scale up your organoid research. Learn how to obtain consistent, high-quality PDOs and integrate them seamlessly into high-throughput assays.

CellXpress.ai Automated Cell Culture System

Molecular Devices®

The CellXpress.ai™ Automated Cell Culture System is an AI-driven cell culture innovation hub that gives your team total control over demanding cell culture feeding and passaging schedules—eliminating time in the lab while maintaining a 24/7 schedule for growing and scaling multiple stem cell lines, spheroids, or organoids.

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AutomationAutomation in laboratories and manufacturing processes enhances efficiency, precision, and scalability by reducing the need for manual intervention. It plays a critical role in improving productivity, minimizing human error, and accelerating workflows in fields like diagnostics, drug development, and industrial testing. Automation technologies include robotic systems, automated liquid handlers, and process control systems that streamline complex tasks and ensure consistent, reproducible results. Explore our peer-reviewed product directory to discover the best automation solutions, compare options, read user reviews, and get prices directly from manufacturers.Organoids
Scaling organoid production with automation