Scaling up organoid culture using the MANTIS Liquid Handler: A case study with MIT

23 Dec 2022

In this application note, Formulatrix describes how, using the MANTIS® liquid handler from FORMULATRIX, researchers within the Shalek laboratory at the Massachusetts Institute of Technology (MIT) were able to rapidly screen >450 small molecules at a range of doses for their capacity to enhance differentiation of Paneth cells within small intestinal organoids.

MANTIS® Liquid Dispenser

FORMULATRIX®, Inc.

The MANTIS automated liquid dispenser excels at accurate, low-volume dispensing in a wide variety of scientific workflows. The system is an easy and affordable solution to quickly increase the reproducibility and quality of your research as well as the throughput and efficiency of your laboratory. 

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Cell / Tissue CultureCell culture or tissue culture is used to study the biology of cells or tissues and to isolate cellular products in an environment which can be manipulated and well defined. Accurately control your culture environment with bioreactors or culture incubators, bind your cells to a surface or together with an extracellular matrix. Distinguish cell types with differential media or proliferate cells with certain characteristics using selective media. Enrich your media with supplements such as growth factors, sera and vitamins. Find the best cell and tissue culture products, kits and equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Automated Liquid HandlingAutomated liquid handling equipment is used to mix, dilute and dispense allotted volumes of liquid into microplates and other vessels automatically. The robotic, liquid handling arms can dispense from single channel to 3456 multichannel as well as operate nanoliter dispensing, enabling high throughput of samples. Find the best automated liquid handlers in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.OrganoidsLiquid HandlingLiquid handling involves the precise transfer, mixing, and dispensing of liquids in laboratory settings. It is essential for accurate and consistent results in biological, chemical, and pharmaceutical research. Automated liquid handling systems improve efficiency and reduce human error in sample preparation and analysis. Explore liquid handling tools in our peer-reviewed product directory; compare products, read customer reviews, and get pricing directly from manufacturers.
Scaling up organoid culture using the MANTIS Liquid Handler: A case study with MIT