ResourceSpectroscopy
RT-MALS end-point determination of a polysaccharide depolymerization process
23 Jan 2020Current methods to monitor molar mass during polysaccharide production employ off-line SEC-MALS analysis, during which a single run can take up to 30 minutes. With a typical depolymerization time of about 90 minutes, off-line analytics cannot provide timely feedback on reaching the endpoint. In this application note, Wyatt Technology demonstrates how real-time multi-angle light scattering (RT-MALS) fills this need and ensures that the process ends as soon as the endpoint criterion is achieved.
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Sample PreparationSample preparation can improve the quality and speed of separation techniques. Products to assist sample preparation include filtration equipment, evaporators, membranes and sieves.PolymersPolymers are large molecules made up of many repeat units. Natural polymers such as DNA and proteins are essential to life, whereas synthetic polymers such as polystyrene and polyethylene are used widely due to their functionality. Typical techniques for analysis include GPC, SEC, DSC, FT-IR and NMR.BiotherapeuticsBiotherapeutics are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or in <i>in vivo</i> diagnostics. The most well-known example of a biotherapeutic product, and the first to be approved for therapeutic use, was recombinant human insulin.