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Robustness characterization of a quantitative whole blood assay using PaperSpray technology for clinical research

Thermo Fisher Scientific
10 Nov 2023

This application note describes a method for quantitative and robust analysis of EDDP (2-ethylidene1,5-dimethyl-3,3-diphenylpyrrolidine), an opioid metabolite, in human whole blood for clinical research using the VeriSpray Paper Spray ion source coupled with a TSQ Quantis mass spectrometer.

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VeriSpray™ PaperSpray Ion Source

Thermo Fisher Scientific

If you are dealing with a rising backlog of samples due to an insufficient chromatography-based solution, the Thermo Scientific VeriSpray PaperSpray ion source for mass spectrometry is a valuable alternative solution for MS analysis. This paper spray ionization technique provides direct sample analysis capability with your triple quadrupole mass spectrometer, eliminating the need for chromatographic based separation, simplifying your workflow and getting to results faster.

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TSQ Quantis™ MD Mass Spectrometer

Thermo Fisher Scientific

Achieve the sensitivity to perform routine quantitative analyses with remarkable speed and robustness. The Thermo Scientific™ TSQ Quantis™ MD Series mass spectrometer can be used by clinical diagnostic laboratories to meet their routine requirements for laboratory developed tests (LDTs). With Active Ion Management (AIM+) technology,the TSQ Quantis MD Series delivers confident quantitation for routine analyses of human specimens.

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.

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Robustness characterization of a quantitative whole blood assay using PaperSpray technology for clinical research