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Retrospectively monitor cocaine consumption from user toenail clippings

3 Dec 2019

In this application note, MP Biomedicals outlines how to retrospectively monitor long-term recreational and dependent cocaine use via toenail clippings and scrapings as an alternative to hair.

FastPrep-24™ 5G

MP Biomedicals

The FastPrep-24™ 5G Instrument is quite simply the most advanced sample preparation system ever!   The only high-speed benchtop homogenizer featuring microprocessor-controlled, Hi-Def Touch Screen Programming makes the 5G the ultimate in ease, speed and performance for sample preparation applications where it is necessary to grind, lyse, or homogenize difficult and routine samples, allowing easy and reproducible isolation of stable RNA, active proteins and full-length genomic DNA. Applications include but are not limited to: biological tissues, fluids and excretions cell cultures environmental sample other inorganic solid matrices. The FastPrep-24™ 5G Instrument uses a unique, optimized motion to disrupt cells through the multidirectional, simultaneous beating of specialized Lysing Matrix beads on the sample material. Samples and buffers are added to Lysing Matrix Tubes containing specialized Lysing Matrix beads, supplied ready-to-use, certified nuclease-free and in a variety of sample type specific compositions. The sample tubes remain securely sealed during the processing and the single use design eliminates cross-contamination. Program parameters are easily set using the touch screen user interface, or choose from many Recommended Programs stored on the 5G's onboard computer. With a simple touch of the "run" button, in less than a minute your samples are completely lysed, super fast, every time! The highest power settings available ensure that DNA, RNA and proteins, even from difficult samples, are quickly liberated into the protective buffer, thus preserving their biological function. FastPrep-24™ 5G Exclusive Features Powerful - Highest speed range available, ideal for a wide range of applications and protects your sample Optimized - Cycle and pause programmable for true walk-away operation Convenient - >70 Recommended Programs for easy optimizations Intuitive - Interactive user-friendly interface and touchscreen Flexible - Optional sample holders allow processing from 2 - 50 mL tubes, under ambient or cryogenic conditions Smart - Integrated USB Port allows for software updates to be installed, and run history data to be downloaded to a laptop Safe - Electromechanical dome latch automatically secures processing chamber, with a simple finger touch Complete - Lysing Matrix Tubes and Purification Kits from One Source

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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drugs of AbuseA drug of abuse is a drug that has been taken for non-medical purposes. Such drugs can have mind-altering effects, with some causing dependence and addiction.Drug TestingIt is essential to test the efficacy and toxicity of drugs at every stage of their development to ensure that a pharmaceutical product is fit for purpose and safe for use before reaching the stage of mass production and distribution.
Retrospectively monitor cocaine consumption from user toenail clippings