RenataDX System: Analytical performance for butyl esters of amino acids, free carnitine, and acylcarnitines in dried blood spots

The Waters RenataDX Screening System enables flowinjection analysis and quantification of organic compounds in biological matrices. In this application note, Waters describes a test of the analytical performance of the RenataDX Screening System for the analysis of butyl esters of amino acids, free carnitine, and acylcarnitines in dried blood spots. Dried blood spot (DBS) control samples were extracted. Derivatized extracts from DBS control samples were analyzed with the RenataDX System, under the control of MassLynx IVD Software (v4.2), with data processed using IonLynx Application Manager. Here, the Waters RenataDX System has demonstrated the capability to measure a subset of butyl esters of amino acids, free carnitine, and acylcarnitines. The endogenous concentration of arginine was near the limit of detection of the RenataDX System.