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Reduction of Matrix Effects Using LC-MS/MS with Online Extraction for Quantitation of Antibiotics in Milk
16 Mar 2015In this application note, a study was carried out using the Bruker EVOQ Elite liquid chromatography mass spectrometer (LC-MS/MS) with an online extraction (OLE) option to quantify 8 antibiotics in milk. The milk matrix clean-up was performed online using an innovative UHPLC integrated with a binary pump and one loading pump. The EVOQ Elite with OLE showed a significant reduction of matrix effects and excellent linearity, with online extraction providing an effective, timesaving approach for clean up.
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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AntibioticsAntibiotics are substances that kill or inhibit the growth of microorganisms, such as bacteria and fungi. They are essential in the treatment of infections and in preventing disease spread. Explore antibiotics research and diagnostic tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.