ResourceSeparations
Reduction of Matrix Effects from Filter Effluents using Pall Acrodisc® MS Syringe Filters for LCMS Sample Preparation
19 Apr 2012This application note compares the cleanliness of the effluents from Pall’s Acrodisc MS syringe filters with two other commercially-available, alternative syringe filters from Competitor A (PVDF filter) and Competitor B (hydrophilic PTFE filter) by evaluating the ME due to potentially interfering extractable/leachable compounds in the LCMS analysis of three drug substances.
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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Matrix EffectsFilter Effluent