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Recommendations for titration methods validation
17 Dec 2021The objective of validation of an analytical procedure is to demonstrate that it is suitable for its intended purpose. In this white paper, Metrohm provides some recommendations for the validation of titration methods.
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TitrationTitration is an analytical technique for determining substance concentration in a solution. For titration consider a manual or automated system, volumetric or coulometric reagent addition and indication by a potentiometer, spectrometer, turbidometer or by the Karl Fischer method. Other features of titration to consider include burettes, reagents, concentration range, reaction time and autosamplers.Method ValidationMethod validation is the process used to prove that the analytical procedure used for a particular test is capable of providing suitable data.