SelectScience
Join Free
Accelerating Science
ResourceAnti-Doping Science

Quantitative analysis of cannabinoids in urine and oral fluid using reactive PS-MS for forensic toxicology

Thermo Fisher Scientific
20 Jun 2024

Chromatographic mass spectrometry methods are considered the gold standard in forensic drug testing due in part to their high sensitivity and selectivity. Unfortunately for many confirmatory tests, extensive sample preparation steps and lengthy run times are required for adequate analysis. Paper spray mass spectrometry (PS-MS) is a potential alternative mass spectrometry method featuring negligible sample preparation, rapid analysis, and adequate sensitivity and selectivity.

This technical note from Thermo Fisher Scientific demonstrates sensitive and accurate quantitation of THC in oral fluid and THC-COOH in urine, through PaperSpray MS with the VeriSpray ion source, while avoiding lengthy sample preparation. It also finds that sensitivity is dramatically increased using Fast Red RC derivatization alongside reactive paper spray mass spectrometry.

Related products

Request Quote for All Products

VeriSpray™ PaperSpray Ion Source

Thermo Fisher Scientific

If you are dealing with a rising backlog of samples due to an insufficient chromatography-based solution, the Thermo Scientific VeriSpray PaperSpray ion source for mass spectrometry is a valuable alternative solution for MS analysis. This paper spray ionization technique provides direct sample analysis capability with your triple quadrupole mass spectrometer, eliminating the need for chromatographic based separation, simplifying your workflow and getting to results faster.

(2)

Links

Thermo Fisher ScientificCompany website

Tags

Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer. Toxicology / Drugs of Abuse TestingToxicology and Drugs of Abuse Testing is the investigation into toxic and illegal substances found at the scene of a crime or from a suspect and / or victim associated with a scene of a crime. Analyzers, immunoassays and drugs of abuse test kits and presumptive test kits are an essential aspect of toxicology investigation.Quantitative AnalysesQuantitative analyses involve measuring the amount or concentration of a substance in a sample using analytical techniques. These analyses are essential in fields like chemistry, biology, and environmental science. Explore quantitative analysis tools in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.Forensic ToxicologyForensic toxicology is used to determine cause of death, drug use and contaminations. Toxicological evaluations are commonly used in analytical chemistry, clinical, life sciences and forensics.Derivatisation

Related resources

Quantitative analysis of cannabinoids in urine and oral fluid using reactive PS-MS for clinical research and forensic toxicology