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Purification of Flavanone Glycoside with Reveleris® System Improves Polar Compound Isolation
23 Dec 2010This application note explains how using the Reveleris® system with RevealX™ technology and the high capacity Reveleris® amino cartridges, unreacted or even degraded reagents that may not be detected with UV detection can be isolated from a mixture of neohesperidin, hesperitin and neo-hesperidose during neohesperidin synthesis. Neohesperidin is an intensely bitter flavanone glycoside used for producing non-sugar sweetners for diabetes related therapy, naturally available from bitter orange.
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Flash ChromatographyFlash chromatography is a fast-preparative column chromatography technique used for separation and purification of liquid analytes. Flash chromatography systems use small silica gel particles for separation and a pressurized gas for driving the solvent through the column or pre-packed cartridge. Find the best flash chromatography equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Medicinal ChemistryMedicinal chemistry is a broad discipline encompassing the design, identification, synthesis and development of chemicals in drug discovery. It includes a number of techniques covering structural biology, synthetic chemistry and molecular biology. Technologies used in medicinal chemistry include ADME, lab-on-a-chip, high content screening and assay assembly.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.Biopharmaceutical AdvancesBiopharmaceutical advances follow the development of pharmaceuticals derived from biotechnology, also known as biotechnology medicines. Biopharmaceuticals may be produced from cell lines, plants, or microbial cells. Important considerations of biopharmaceutical use include application, cost, production process and purification.