Purification of Delicate Compounds with RediSep Rf Gold® Diol and Cyano Columns

Many compounds are difficult to purify because they decompose on the column. This application note demonstrates the synthesis and purification of an epoxide compound with a RediSep Rf Gold Diol and RediSep Rf Gold Cyano column. The epoxide makes an excellent model for other unstable compounds as epoxides commonly decompose on silica gel. Unstable compounds are often purified using a series of liquid-liquid extractions. Purifying such compounds on a column where the amount of solvent used and evaporation is reduced is desirable.