ResourceSpectroscopy
Protein post-translational modifications: Translating diversity to discovery
15 Feb 2024Following synthesis, the majority of proteins will experience modifications. Over 200 different post-translational modifications (PTMs) have been identified, with the most widely researched being phosphorylation, glycosylation, acetylation, methylation, nitrosylation, acylation, and ubiquitylation. Identifying and understanding these significant mechanisms is critical to the study of basic cell biology as well as in disease pathogenesis. In this whitepaper, RayBiotech presents the detection methods and techniques of protein PTMs, highlighting their significant role in cellular processes and disease pathways. RayBiotech explains how its PTM detection kits can be beneficial for the development of innovative therapeutic interventions. Its suite of PTM profiling tools includes easy-to-use antibody arrays to screen up to 8,000 target proteins for acetylation, palmitoylation, oxidation, glycosylation, or phosphorylation signatures.
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Mass SpectrometryMass spectrometry (MS) is a powerful analytical technique used to identify and quantify molecules based on the mass-to-charge ratio of gas-phase ions. It provides detailed information about the structure, composition, and properties of compounds and is widely used across fields such as environmental monitoring, materials science, drug discovery and development, food and beverage testing, and wider chemical research. Key MS techniques include tandem mass spectrometry (MS/MS), liquid chromatography–mass spectrometry (LS-MS) and inductively coupled plasma (ICP-MS). Choosing from these wide range of techniques and technologies can be a daunting task, so keep up to date with scientific applications, performance expectations, and customer reviews here all in one place. Visit our product directory to receive quotes direct from the manufacturer.
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