ResourceSpectroscopy

Pros and Cons of Using Correlation versus Multivariate Algorithms for Material Identification via Handheld Spectroscopy

20 Jan 2014

In this white paper discusses the two most common mathematical representations used with handheld Raman spectroscopy as decision making tools for spectroscopic data: Hit Quality Index (HQI) and significance level (p-value). Specific examples for the use of each tool are discussed.

NanoRam® Handheld Raman Spectrometer

B&W Tek, Inc.

The NanoRam® is the state-of-the-art compact handheld Raman analyzer designed for use by non-specialists, and easily operates single-handedly.It allows rapid development of libraries and methods for material identification and verification within cGMP compliant facilities, whether in the lab, the warehouse, the loading dock or the field. Raman spectroscopy is an approved method by US Pharmacopeia, European Pharmacopeia, Pharmacopeia of the People’s Republic of China and is a well-recognized method for compliance with the PICS GMP guide to provide 100% assurance of the identity of each container of starting material.The NanoRam is fully compliant with all governing regulations including 21 CFR Part 11 and Part 1040.10. B&W Tek offers a wide variety of services including assistance with method and/or new library development and other services such as support with IQ/OQ/PQ validation.NanoRam® Handheld Raman Spectrometer Features: Intuitive Software – a user-friendly tool for both technical & non-technical users to make their job easier Versatility – measure a variety of samples in a variety of environments and packaging with just one unit Data Reproducibility – superior hardware ensures that results are consistent and reliable Performance – robust multivariate algorithms guarantee accuracy when testing and identifying materials

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Raman SpectroscopyRaman spectroscopy is used to discern the vibrational and rotational states of molecules and hence the chemical composition of a sample by measuring the inelastic scattering of monochromatic light. Explore a range of Raman spectrometers, including handheld/portable Raman spectrometers for QC/QA labs and in situ spectrometers for processes. Conduct Raman imaging for microanalysis of mixed samples using a Raman microscope. Raman spectrographs are also available. Find the best Raman spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Process ChemistryProcess chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.PharmaceuticalsPharmaceuticals are medicinal drugs used in healthcare to diagnose, prevent, cure and treat illnesses. Pharmaceuticals that are excreted after use appear in wastewater and can have detrimental effects on the environment.
Pros and Cons of Using Correlation versus Multivariate Algorithms for Material Identification via Handheld Spectroscopy