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Profiling Analysis of Mono-, Di- and Tri-phosphate Nucleotides Using Capillary Ion Chromatography Mass Spectrometry

Thermo Fisher Scientific
6 Oct 2013

There have been extensive studies of using nucleoside analogs as prodrugs in anti-cancer, anti-viral and immunosuppressive therapy, and monitoring of their activated nucleotides metabolites is of paramount importance to understand the pharmacology. This poster evaluates a quantitative method for targeted metabolic profiling analysis of mono-, di-, and tri-phosphate nucleotides using capillary ion chromatography tandem mass spectrometry (Cap IC-MS-MS).

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Capillary Ion ChromatographyIon Separation

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Profiling Analysis of Mono-, Di- and Tri-phosphate Nucleotides Using Capillary Ion Chromatography Mass Spectrometry