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Process monitoring from raw materials to finished products in biopharma

8 Nov 2024

As part of current good manufacturing practice (cGMP), many pharmaceutical manufacturers are adopting process analytical technologies (PAT), quality by design (QbD), or process validation (PV) to provide continuous process verification and analysis. Analytical instruments may be used for at-line and in-process monitoring to bring the technology to the sample to speed up the analysis process and enable more flexibility from a smaller footprint. Discover efficient process monitoring solutions in biopharmaceutical production with Thermo Scientific analyzers and bioreactors.

microPHAZIR RX

Thermo Fisher Scientific

The Thermo Scientific™ microPHAZIR™ RX Analyzer is a handheld Near-Infrared (NIR) instrument designed for rapid, on-site raw material identification.   Pharmaceutical manufacturers can obtain reliable material identity verification anywhere in the plant within seconds. The microPHAZIR RX Analyzer provides a portable tool to meet regulatory requirements, improve product quality, cut manufacturing costs, and reduce supply chain risk.  

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Prima BT Bench top Mass Spectrometer

Thermo Fisher Scientific

Prima BT Bench top Mass Spectrometer - Highly reliable, precise, and flexible gas analyzer specifically designed for process development laboratories. The Thermo Scientific Prima BT Bench top Mass Spectrometer is an industrial laboratory gas analyzer based on scanning magnetic-sector mass spectrometry. Designed for continuous operation in a process environment, the Prima BT mass spectrometer is simple to operate and easy to maintain. The primary feature of the Prima BT mass spectrometer is the magnetic sector analyzer. This field-proven technology has demonstrated the strongest performance for industrial on-line gas analysis. Magnetic sector technology offers precision, accuracy, long intervals between calibrations, and resistance to contamination. The flat-topped peak profile ensures that the gas composition measurements are highly reproducible and the laminated magnet enables high scanning speeds. The Prima BT mass spectrometer offers robust performance in the presence of gases and vapors that have the potential to contaminate internal vacuum components. As the ions are extracted from the ion source at high energy, excellent stability is achieved for low molecular weight compounds such as hydrogen and helium. Prima BT Bench top Mass Spectrometer Features: Scanning Magnetic-sector technology 16-port Rapid Multistream Sampler (RMS) 6-port Automatic calibration manifold High analytical precision, accuracy, and stability

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Raman SpectroscopyRaman spectroscopy is used to discern the vibrational and rotational states of molecules and hence the chemical composition of a sample by measuring the inelastic scattering of monochromatic light. Explore a range of Raman spectrometers, including handheld/portable Raman spectrometers for QC/QA labs and in situ spectrometers for processes. Conduct Raman imaging for microanalysis of mixed samples using a Raman microscope. Raman spectrographs are also available. Find the best Raman spectroscopy products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.
Streamlining process monitoring in the biopharmaceutical industry