Pharmaceutical Formulations as 7mm and 13mm KBr Pellet Preparations for Comparison
8 Jun 2016IR spectroscopy is a useful tool for group chemical species identification of a wide variety of sample materials, particularly for the classification of “organic” chemical materials based upon carbon atoms being present in the molecular structure. A classic sampling technique for the study of solid sample types by IR transmission spectroscopy is to prepare the solid sample as a potassium bromide (KBr) disc or pellet to mount appropriately and correctly within the sampling area of an infrared spectrometer. This application note shows how a few examples of pharmaceutical formulations as tablets/pills and capsules can be prepared to form both 7mm and 13mm KBr sample pellets produced for comparison.
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Mini-Pellet Press
Specac LtdThe Specac Mini-Pellet Press is an entry-level laboratory hydraulic press for the preparation of high-quality 7mm KBr pellets for transmission FTIR analysis. With a rugged and durable design, this press is intended for regular laboratory use with maintenance-free operation. Specac’s Mini-Pellet Press is designed to be used on a laboratory benchtop, but is small in size and light enough in weight to allow it to be moved to different points of use or stored when not required. Full hydraulic operation, and an innovative sealed hydraulic unit, allows the user to apply the required load for sample preparation through the simple rotation of a load knob. Reproducible load for pressing high-quality KBr pellets suitable for quantitative studies is facilitated by use of integrated pressure gauge. The Specac Mini-Pellet Press is also available as part of a Basic Solid Pack. This pack is equipped with a range of sample preparation components necessary for FTIR solid sample analysis by transmission, including the Mini-Pellet Press, a 7mm Pellet Die Assembly, 7mm Disc Holder for a standard 3” by 2” mount, a pair of spare Pellet Ring Holders, a Pestle and Mortar, and KBr Powder (50g).
Atlas™ Manual Hydraulic Press
Specac LtdThe Specac Manual Hydraulic Press is available in 15 and 25 ton load configurations for a wide variety of laboratory pressing applications. It is ideally suited to the manufacture of KBr pellets for FTIR spectroscopy as well as sample pellets and targets for other spectroscopic techniques such as XRF, Terahertz, and laser ablation spectroscopy.